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國立臺灣大學生物機電工程學系

學術活動

【專題討論演講】- 應用於生物感測與細胞培養的微流體裝置之發展 (中央研究 院應科中心-鄭郅言教授)
  • 發布單位:生物機電工程學系

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生 物 感 測 器 是 由 analyses, biocompatible layer, transducer, amplifier, microelectronics 所構成,而微流道是指透過極窄通道移動極少量液體的裝置。在鄭教授的研究中顯示 TEP 所形成的電場對於傷口(上皮細胞)的修復有幫助,可觀察 PDGE-R, Eph-R 的基因 marker、ROS 的增加;另一項研究將大腸桿菌與ciprofloxacin 結合,用於偵測蛋奶中的細菌;以 machine learning 搭配 CMOS camera 用於判斷樣品是否為毒品;最主要鄭教授是研究電場對癌細胞的影響,他發現: 1)電場使癌細胞有遷移現象;2)加入 doxycycline 可降低癌細胞對電場的方向性,但不會抑制其活性。

 

撰寫者:碩士班學生周芯妤


Biological sensors are complex devices comprising several components: analyses, a biocompatible layer, a transducer, an amplifier, and microelectronics. In tandem with these elements, microfluidics refers to devices designed for the precise manipulation of minute liquid volumes through extremely narrow channels. Professor Zheng's research has unveiled the beneficial effects of the electric fields formed by Transcutaneous Electrical Stimulation (TEP) on wound healing, particularly in the context of epithelial cell repair. This effect is evident through the observation of gene markers such as PDGE-R and Eph-R, as well as the increased presence of reactive oxygen species (ROS).Another study conducted in Professor Zheng's laboratory involved the conjugation of Escherichia coli (E. coli) with ciprofloxacin for the purpose of detecting bacterial contamination in egg and dairy products. Additionally, machine learning techniques were employed in conjunction with a Complementary Metal-Oxide-Semiconductor (CMOS) camera to determine the presence of illicit substances in samples. Most notably, Professor Zheng's primary focus revolves around investigating the impact of electric fields on cancer cells. His findings suggest that: 1) electric fields induce migratory behavior in cancer cells, and 2) the addition of doxycycline can reduce the directed response of cancer cells to electric fields without inhibiting their overall activity.

 

Author: Master student: Xin-Yu Zhou